Darier's Disease Successfully Treated with Tofacitinib: A Case Report.

ABSTRACT:

Introduction

Darier's disease (DD) is a rare autosomal dominant genodermatosis associated with high morbidity and currently has no cure. Janus kinase (JAK) inhibitors are increasingly being investigated in dermatology for refractory and difficult-to-treat conditions. In this case report, we present a patient with refractory DD who showed a satisfactory response to this therapy.

Case presentation

A 42-year-old woman who developed pruritic brown papular lesions on her trunk, particularly under the breasts, groin, and neck, was presented. A biopsy confirmed DD, and she was treated with adalimumab, which failed to provide clinical improvement. The patient was then started on tofacitinib 10 mg daily, leading to disease stabilization. Due to persistent itching and new lesions, the

SUBMITTER: Behrangi E 

PROVIDER: S-EPMC12659601 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature