Efficacy and Blood Concentrations of Cetuximab in a Hemodialysis Patient with Tongue Squamous Cell Carcinoma: A Case Report.

ABSTRACT:

Introduction

Cetuximab is an effective therapy for unresectable locoregionally advanced head and neck cancer, but for patients with end-stage renal disease (ESRD), clinical trials seldom provide evidence for the efficacy and safety of cetuximab.

Case presentation

We report this case of 46-year-old male patient with stage IVa tongue squamous cell carcinoma who is on maintenance hemodialysis for diabetic nephropathy. He tolerated the therapy well and had a stable disease of the carcinoma. We determined cetuximab concentration and showed that pharmacokinetics of cetuximab in this ESRD patient was similar to healthy subjects.

Conclusion

Cetuximab can be used safely and effectively in head and neck cancer patients with ESRD, and we have provided an example of pharmacokinet

SUBMITTER: Niu TT 

PROVIDER: S-EPMC12659662 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature