Trophoblast cell-surface antigen 2 expression in digestive neoplasms: a promising target for antibody-drug conjugates.

ABSTRACT:

Background

Trophoblast cell-surface antigen 2 (Trop2), a transmembrane glycoprotein overexpressed in multiple cancers, plays crucial roles in tumor progression and therapy resistance, yet its expression patterns and clinical significance in digestive cancers remain incompletely characterized.

Methods

This retrospective study analyzed a consecutive cohort of 2370 patients with histologically confirmed digestive cancers (804 gastric [GC], 1,384 colorectal [CRC], and 182 pancreatic cancers [PC]). Comprehensive clinicopathological data were systematically collected. Trop2 expression was quantitatively evaluated by immunohistochemistry and classified into Trop2-negative, Trop2-low, and Trop2-high based on the product of staining intensity and the proportion of positive tumor cell

SUBMITTER: Yang J 

PROVIDER: S-EPMC12659696 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature