MRI-based radiomics nomogram to predict complete response to definitive chemoradiation in patients with anal cancer.

ABSTRACT:

Objectives

Treatment response to definitive chemoradiation (dCRT) in patients with anal cancer varies significantly, with a subset experiencing persistent or progressive disease despite therapy. Radiomics extracts quantitative features from radiological images, with the potential to develop predictive tools to assess treatment response. We aim to develop and validate an MRI-based radiomics nomogram to predict response to dCRT in patients with anal cancer.

Methods

A single-institutional retrospective analysis of 45 patients with anal cancer treated with dCRT was performed. Radiomic features were extracted from pre-treatment T2-weighted MRI scans, and predictive models were constructed. Clinical and radiomic features were analysed to develop the nomogram. Internal validation w

SUBMITTER: Temperley HC 

PROVIDER: S-EPMC12659730 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature