Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System.

ABSTRACT: Stem cell niches are complex multi-signalling networks comprised of molecular cues and physical interactions, orchestrated by niche-resident cells and the extracellular factors they produce. The bone niche specifically houses haematopoietic stem cells (HSCs), a critical cell type responsible for producing all blood and immune cells throughout life. Currently, how niches facilitate an ideal environment with simultaneously coordinating both intrinsic and extrinsic cellular signals is unknown. Studies presented here identify the existence of unique extracellular vesicle (EV)-defined niches within the haematopoietic system of human individuals. Bridging studies using proteomic signatures, nanoparticle characterization at single-vesicle resolution and machine learning-based techniques reveal th

SUBMITTER: Grenier-Pleau IJ 

PROVIDER: S-EPMC12659769 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature