Comparison of Gastric Cancer Models Using Different Dimensions In Vitro.

ABSTRACT:

Background

Gastric cancer (GC) is one of the most common cancers worldwide due to its late stage of diagnosis. More efficacious models are required to serve as experimental representatives to enhance the effectiveness of various drugs, select suitable treatment regimens for patients, and further investigate the molecular pathological mechanism of GC.

Aims

This study utilized four GC cell lines and patient-derived tumor cells (PDTCs) to explore the advantages and disadvantages of the 2D, spheroid, and organoid models, reveal the growth characteristics, drug sensitivity differences, and potential mechanisms of GC cells in different culture models, so as to promote the development of GC models.

Methods and results

A series of experimental approaches were employed, encomp

SUBMITTER: Zheng W 

PROVIDER: S-EPMC12659928 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature