Serum Proteomic Profiling Uncovers LGALS3BP as a Potential Biomarker for Idiopathic Pulmonary Arterial Hypertension.

ABSTRACT:

Background

Idiopathic pulmonary arterial hypertension (IPAH) is a progressive and fatal disease characterized by pathological pulmonary vascular remodeling and right heart failure. Current biomarkers for IPAH demonstrate limited clinical utility, necessitating the discovery of noninvasive serum biomarkers to facilitate early diagnosis and prognosis.

Objective

To identify novel serum biomarkers for IPAH using tandem mass tag-based quantitative proteomics and validate their clinical relevance.

Methods

Serum samples from five IPAH patients and five age/sex-matched healthy controls (discovery cohort) were analyzed by tandem mass tag proteomics to screen differentially expressed proteins (DEPs). Functional enrichment and protein-protein interaction network analyses were pe

SUBMITTER: Li M 

PROVIDER: S-EPMC12659930 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature