Effect of Bariatric Surgery on the Pharmacokinetics of Codeine, Oxycodone and Tramadol-A Case Series.

ABSTRACT:

Background

The impact of bariatric surgery on the pharmacokinetics of codeine, oxycodone or tramadol is largely unknown.

Methods

In patients treated with these opioids before and after bariatric surgery, serial drug concentrations were measured throughout a dose interval preoperatively and 1, 6 and 12 months postoperatively.

Results

Eight patients treated with codeine (n = 2), oxycodone (n = 2) or tramadol (n = 4) were included. In the patients using codeine, the area under the concentration-time curve during a dose interval (AUC) was moderately increased for the active metabolites morphine and morphine 6-glucuronide 6-12 months after bariatric surgery. For oxycodone, there were only negligible AUC changes. In the tramadol group, there were no discernible AUC changes

SUBMITTER: Spigset O 

PROVIDER: S-EPMC12659968 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature