A Pragmatic Trial of Glucocorticoids for Community-Acquired Pneumonia.

ABSTRACT:

Background

Adjunctive glucocorticoids may reduce mortality among patients with severe community-acquired pneumonia (CAP) in well-resourced settings. Whether these drugs are beneficial in low-resource settings with limited diagnostic and treatment facilities is unclear.

Methods

In this pragmatic, open-label, randomized, controlled trial conducted in 18 public hospitals in Kenya, we assigned adult patients who had received a diagnosis of CAP and who did not have a clear indication for glucocorticoids to receive either standard care for CAP or oral low-dose glucocorticoids for 10 days in addition to standard care. The primary outcome was death from any cause at 30 days after enrollment.

Results

A total of 2180 patients underwent randomization (1089 assigned to the glucoc

SUBMITTER: Lucinde RK 

PROVIDER: S-EPMC12659994 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature