Sex-specific associations of preoperative serum uric acid levels with mortality and morbidity in non-cardiac surgeries: a single-center retrospective study.

ABSTRACT:

Background

The sex-specific association between serum uric acid (SUA) levels and postoperative outcomes in elective non-cardiac surgery remains unclear. This study aimed to identify sex-specific SUA thresholds and their impact on short- and long-term outcomes.

Methods

A retrospective analysis of 295 267 patients (2012-2021) undergoing non-cardiac surgery was conducted. Patients were stratified by preoperative SUA levels: for males (< 4 to ≥ 9 mg/dl) and females (< 3 to ≥ 8 mg/dl), with mid-range levels as reference. Mortality (30-day to overall) and complications were assessed using Cox and logistic regression. Cubic splines evaluated nonlinear trends, with subgroup analyses by age and surgical risk.

Results

SUA levels exhibited a nonlinear, sex-specific association w

SUBMITTER: Sim JH 

PROVIDER: S-EPMC12660039 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature