Association between sepsis and all-cause and cause-specific premature mortality: a prospective cohort study.

ABSTRACT:

Objective

This study aimed to examine the association between sepsis, including its subtypes, and all-cause and cause-specific premature mortality.

Methods

This population-based prospective cohort study included 371,558 participants from the UK Biobank recruited between 2006 and 2010. Sepsis was identified from hospital records using ICD-10 codes. Cox proportional-hazards models estimated adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for premature mortality.

Results

Among 371,558 participants, 47,149 (12.7%) were diagnosed with sepsis, including 21,148 with implicit sepsis, 620 with explicit sepsis, and 25,381 with both. Sepsis was associated with a higher risk of all-cause premature mortality (aHR 2.36, 95% CI 2.26-2.46). Cause-specific analyses sh

SUBMITTER: Kang W 

PROVIDER: S-EPMC12660079 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature