Longitudinal clinical course, treatment outcomes, and relapse patterns in alopecia areata: a prospective cohort study.

ABSTRACT:

Background

Alopecia areata (AA) is a common autoimmune hair loss disorder with a highly variable course and substantial psychosocial impact. Evidence from long-term prospective cohorts remains limited. To characterize the natural history, treatment outcomes, relapse patterns, quality-of-life changes, and safety profile of AA over 52 weeks in a real-world clinical setting.

Methods

In this single-center prospective cohort, 400 patients with AA and 80 healthy controls were followed for 52 weeks, with assessments at weeks 4, 12, 24, 36, and 52. Disease severity was quantified using the Severity of Alopecia Tool (SALT). Primary outcomes included SALT50 and SALT90 achievement at week 24; secondary outcomes were relapse at week 52, patient-reported outcomes [Dermatology Life Qualit

SUBMITTER: Wenjie Y 

PROVIDER: S-EPMC12660087 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature