Association between severe acute pancreatitis and new-onset diabetes: a propensity score-matched real-world study.

ABSTRACT:

Introduction

Acute pancreatitis (AP) is an inflammatory disease of the exocrine pancreas characterized by tissue damage and sometimes necrosis. However, whether severe AP is associated with an increased risk of incident diabetes remains unclear based on real-world data. This study aims to examine the relationship between severe AP and new-onset diabetes after hospitalization.

Methods

We conducted a retrospective cohort study using the Merative™ MarketScan® claims database (2016-2023), identifying patients with AP and no prior history of diabetes at baseline. The exposure, severe AP, was defined by any of the following during hospitalization: pancreatic necrosis, hemodialysis, organ failure, or mechanical ventilation. We used multivariable stratified Cox proportional hazards

SUBMITTER: Ba DM 

PROVIDER: S-EPMC12660104 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature