Oral Methods of Microbiota Manipulation for Depression Symptoms: A Systematic Review: Methodes orales de manipulation du microbiote pour traiter les symptomes de depression : Une revue systematique.

ABSTRACT: ObjectiveThe effectiveness of current treatment options for depressive symptoms has been widely investigated with acknowledgment that some patients were either not adequately responding to treatment, finding the existing treatment intolerable, or otherwise prefer alternative options. There is increasing interest in microbiota modulation as an alternate form of depression treatment, with a growing number of trials and reviews on the subject published in the last five years. This systematic review aimed to analyze all completed randomized control trials (RCTs) that assessed depression symptoms in adults not using antidepressants, before and after oral methods of microbiota manipulation.MethodAll completed parallel-arm RCTs that assessed depression symptoms in adult participants before and af

SUBMITTER: Oprea A 

PROVIDER: S-EPMC12660127 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature