Reporting of management and outcomes in the hemolytic disease of the fetus and newborn: a systematic literature review.

ABSTRACT:

Objective

This systematic literature review aimed to identify outcomes and provide a foundation for the development of a core outcome set in HDFN applicable for use in future clinical trials.

Study design

The bibliographic databases MEDLINE, Embase, EBM Reviews, and EconLit were searched from 2005 until 2023. Primary research studies were included. Outcomes were systematically extracted from the publications' abstract and categorized into maternal, obstetric, neonatal, long-term, and patient-reported outcomes (PROs).

Results

238 included studies reported 104 different outcomes. Outcomes related to HDFN-specific treatments were the most frequently reported across studies. Long-term outcomes as well as PROs were underutilized in the screened literature.

Conclusion

SUBMITTER: Verweij E 

PROVIDER: S-EPMC12660131 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature