Examining Self-Reported Executive Function and Its Relationship to Patient-Reported Outcomes and Disease-Related Factors in Youth With Childhood-Onset Lupus: A Cross-Sectional Study.

ABSTRACT:

Objective

Up to 60% of youth with childhood-onset systemic lupus erythematosus (cSLE) experience cognitive dysfunction, impacting their quality of life and medication adherence. This study explored self-reported executive function (EF) and its links to patient-reported outcomes and disease-related factors in cSLE.

Methods

This cross-sectional study compared patients aged 10 to 17 years with cSLE to age- and sex-matched controls. The Behavior Rating Inventory of Executive Function Self-Report Global Executive Composite (GEC) T score measured daily EF activities, whereas Patient-Reported Outcomes Measurement Information System (PROMIS) questionnaires assessed pain, sleep, fatigue, anxiety, and depression. Group differences in GEC and correlations with PROMIS scores were analyz

SUBMITTER: El Tal T 

PROVIDER: S-EPMC12660154 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature