Epidemiology and genetic characteristics of coxsackievirus A16 associated with hand-foot-mouth disease in Hangzhou city, Zhejiang province from 2021 to 2024.

ABSTRACT: Hand-foot-mouth disease (HFMD) is a common acute infectious disease in children caused by various enteroviruses (EV). CV-A16 is one of the main pathogens of HFMD, leading to multiple outbreaks of HFMD worldwide, especially in the Asia-Pacific region. This study aims to investigate the molecular epidemiological characteristics of the coxsackievirus A16 (CV-A16) that cause HFMD in Hangzhou, Zhejiang Province from 2021 to 2024. A total of 2,105-laboratory diagnosis HFMD cases were collected, of which 529 were CV-A16 positive samples. The detected number of CV-A16 began to rise in March, peaked in May-August, and then decreased in September. Its distribution was highest in children aged 1-5 years, with more males than females. The phylogenetic analysis indicated that the B1a and B1b subgenotyp

SUBMITTER: Xu Q 

PROVIDER: S-EPMC12660211 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature