Epidemiological shift and clinical characteristics of rhinovirus genotypes in acute respiratory tract infection cases in Kunming, China, from 2019 to 2023.

ABSTRACT:

Background

We aimed to investigate the impact of the coronavirus disease 2019 (COVID-19) outbreak on the genetic diversity and clinical severity of rhinovirus (RV) in acute respiratory tract infection (ARTI) cases in Kunming, China.

Methods

A total of 25,769 patients with ARTI from September 1, 2019 to December 31, 2023 were enrolled. Patients with COVID-19 were excluded from the study. Nasopharyngeal swabs were collected and screened for RV using multiplex reverse transcription polymerase chain reaction. RV-positive samples underwent nested PCR targeting the VP4/VP2 region. The amplified products were sequenced for genotype identification.

Results

A total of 1,017 RV-positive cases were identified (detection rate 3.95%; 1,017/25,769), and all three RV species-RV-A, R

SUBMITTER: Zhang G 

PROVIDER: S-EPMC12660223 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature