IGF1R promotes radiation-induced HSCs activation by regulating DNA-PKcs-mediated DNA damage repair.

ABSTRACT:

Introduction

Ionizing radiation (IR)-induced liver fibrosis is one of the most serious complications of radiotherapy for liver cancer, and the core of its development lies in the activation of hepatic stellate cells (HSCs). The insulin-like growth factor 1 receptor (IGF1R) is commonly known as a growth-promoting kinase receptor that plays a critical role in cell differentiation and tissue reorganization, as well as in promoting the activation of HSCs, tentatively. Additionally, there has been a resurgence of interest in its role in DNA damage repair; nevertheless, the underlying mechanism remains poorly understood. Considering that DNA damage and repair are the most serious radiation injury events, the aim of this study was to explore the mechanism of IGF1R in the activation of HSC

SUBMITTER: Lin J 

PROVIDER: S-EPMC12660224 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature