Triterpenes in breast cancer: a systematic review of preclinical evidence in rodents.

ABSTRACT:

Introduction

Breast cancer poses a significant health problem for women worldwide due to late-stage diagnosis, toxicity of standard therapy and drug resistance. Several therapeutic alternatives, including triterpenes, show promising therapeutic potential and reduced toxicity in vitro and in vivo models.

Methodology

We aimed to systematically review the data provided by rodent models of breast cancer regarding the anticancer effect, mechanisms of action and safety of triterpenes to assess if clinical translation to human studies is supported by current evidence. After a two-phase screening process, our search of PubMed/Medline, Web of Science (WOS) and Scopus databases yielded 163 articles that were included in the analysis.

Results and discussions

Triter

SUBMITTER: Prodea A 

PROVIDER: S-EPMC12660234 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature