Triglyceride-glucose index as a predictor of cardiovascular multimorbidity: a prospective cohort study.

ABSTRACT:

Background

The triglyceride-glucose (TyG) index is a recognized marker of insulin resistance, yet its role in the dynamic progression from cardiovascular disease (CVD) to cardiovascular multimorbidity (CVM) remains unclear. This study aimed to evaluate the association between the TyG index and transitions from a CVD-free state to first CVD and subsequently to CVM.

Methods

In this prospective cohort study, we included participants from the Shanghai Suburban Adult Cohort who were free of CVD at baseline (2016). The TyG index was measured at baseline. Disease transitions were tracked over a median follow-up of 6.26 years. First CVD event was defined as the initial occurrence of coronary heart disease (CHD), stroke, or heart failure (HF), and CVM was defined as the presence of t

SUBMITTER: Bao Y 

PROVIDER: S-EPMC12660249 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature