The oncogenic role of human papillomavirus in breast cancer: a comprehensive systematic review and meta-analysis.

ABSTRACT:

Introduction

Human papillomavirus (HPV) has been increasingly implicated in the pathogenesis of breast cancer (BC), though its role remains controversial. Understanding HPV prevalence and genotype distribution across histological types and regions may clarify this potential association.

Methods

A comprehensive systematic review and meta-analysis was conducted using PubMed, Scopus, and Web of Science databases for studies published between January 1990 and April 2025. Eligible studies reported HPV prevalence in BC tissues stratified by histological classification. Non-English studies, reviews, and those lacking histological stratification were excluded. Data from 49 studies encompassing 4,173 BC cases were extracted. Pooled HPV prevalence and odds ratios (ORs) were calculated

SUBMITTER: Koishybayeva D 

PROVIDER: S-EPMC12660267 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature