Multi-omics analysis reveals the mechanism of selenite reduction by <i>Rhodococcus qingshengii</i> strain isolated from selenium-rich mine.

ABSTRACT: Rhodococcus species are renowned for their metabolic diversity and environmental adaptability, yet their selenium metabolism remains insufficiently studied. In our previously work, we isolated a highly selenite-tolerant strain, Rhodococcus qingshengii PM1, from selenium-rich soils in Enshi, China. To reveal the reduction mechanism of sodium selenite, integrated transcriptomic and metabolomic analyses were conducted. Biochemical assays confirmed that Se exposure induced pronounced oxidative stress in strain PM1 and elicited strong induction of the antioxidant defenses. A total of 308 differential metabolites were detected, with bioactive compounds, organic acids, lipids, secondary metabolites and organoheterocyclic compounds. A total of 1,511 differentially expressed genes wer

SUBMITTER: An J 

PROVIDER: S-EPMC12660274 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature