Allergic sensitization in the tropics: unravelling co-sensitization between crustacean and mites.

ABSTRACT: Crustacean allergy, a common food allergy triggered by immune reactions to proteins in shrimp, lobster, and crab, involves over ten identified allergenic proteins and can lead to severe symptoms, including anaphylaxis. Shellfish-allergic individuals are often sensitized to house dust mites (HDM), yet the specific interrelationships remain unclear. This study analyzed 93 seafood-allergic individuals and selected 54 subjects with positive skin prick tests and/or ImmunoCAP-measured specific IgE to crustaceans. Allergy Explorer 2 (ALEX2) testing was subsequently performed for these individuals. The most reactive mite allergens (in total over 81%), included Der p 1, Der p 2, Der p 23, Der f 1, Der f 2, Gly d 2, and Lep d 2. Der p 23 alone was identified in over 61% of crustacean allergic subjec

SUBMITTER: Heidari S 

PROVIDER: S-EPMC12660283 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature