Storage conditions differentially alter the human tooth enamel proteome.

ABSTRACT:

Introduction

Exfoliated or extracted human teeth are increasingly used as accessible records of health history, biomarkers for predicting health risks, or analyzed for organic components to uncover the mechanisms of atypical development or disease. During formation, dental enamel incorporates and preserves biological information through mineralization, thereby creating a fossil-like record within the tooth structure as it reaches a mineral content of over 95% by weight. The key to unlocking this record depends not only on using appropriate analytical methodologies, but also on how storage conditions affect the original biogenic information.

Methods

To investigate the effect of storage conditions on enamel proteome, human third molars were collected upon extraction and stored

SUBMITTER: Karaaslan H 

PROVIDER: S-EPMC12660288 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature