Graft dysfunction is associated with late CMV infection after kidney transplantation.

ABSTRACT:

Background

Cytomegalovirus (CMV) causes significant morbidity and mortality following kidney transplantation. Late CMV infection (≥2 years post-transplant) is uncommon, and its risk factors and outcomes may differ from earlier infection.

Methods

We conducted a single-centre retrospective study of kidney transplant recipients between 2009 and 2019. Patients were grouped by CMV status: no infection, early infection (<2 years post-transplant), and late infection (≥2 years post-transplant). Clinical characteristics and outcomes were compared.

Results

Donor-positive/recipient-negative (D+/R-) serostatus was observed in 105/710 (14.8%) patients without CMV, 28/42 (66.7%) with early CMV, and 2/28 (7.1%) with late CMV (p < 0.001). Prior rejection occurred in 5.9%, 16.7

SUBMITTER: Zeng A 

PROVIDER: S-EPMC12660292 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature