In-Silico assessment of aortic valve function and mechanics under hypertension.

ABSTRACT:

Introduction

Calcific aortic valve disease (CAVD) is the most common heart valve disorder. While hypertension is a major risk factor, the mechanisms by which elevated blood pressure contributes to calcification are largely unknown. Given the established sensitivity of aortic valve (AV) tissue to mechanical cues, hypertension may subject AV leaflets to a stress state conducive to CAVD. To address this hypothesis, the objective of this study was to compare AV function and mechanics under normotensive (NTN, 120/80 mmHg), pre-hypertensive (preHTN, 125/80 mmHg) and hypertensive (HTN, 130/90 mmHg) conditions using fluid-structure interaction modeling.

Methods

AV flow and leaflet dynamics were computed in an idealized aortic root geometry using the arbitrary Lagrangian-Eulerian app

SUBMITTER: Shar JA 

PROVIDER: S-EPMC12660303 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature