A clotting time longer than 226 s in the INTEM channel of the thromboelastometer is an independent risk factor for mortality during bleeding.

ABSTRACT:

Background and objective

During bleeding the prolongation of the clotting time (CT_INTEM) measured by rotational thromboelastometry (ROTEM) can detect alterations in the intrinsic pathway; however, the significance of a prolonged CT_INTEM for risk stratification in patients with bleeding and the treatment with fresh frozen plasma remains unclear.

Material and methods

A total of 2197 consecutive patients between 2014 and 2020 were retrospectively investigated. All patients were tested by ROTEM during bleeding at the Saarland University Hospital. The CT_INTEM values were compared to mortality at 30 days. Discrimination was assessed with C statistic. Adjusted hazard ratios (adjHR, 95% confidence interval, CI) were calculated with multivariable Cox

SUBMITTER: Bomberg H 

PROVIDER: S-EPMC12660322 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature