Bardoxolone methyl (Bard)-mediated strong suppression of calcium oxalate crystal formation in renal crystal recurrence model.

ABSTRACT: The oxidative stress response during renal crystal recurrence and the dynamics of calcium oxalate (CaOx) crystal formation and clearance in a glyoxylate (GOX)-induced mouse model were examined. CaOx crystals gradually accumulated during five consecutive days of GOX administration, decreased by half in the ten days after administration, and required five weeks for near-complete clearance. HO-1 expression was strongly induced by the initial GOX administration through Nrf2 activation but diminished on continuing the administration. When GOX was readministered after a 10-day interval, HO-1 induction was minimal; however, after a 5-week interval, HO-1 expression returned to its initial levels. Readministration of GOX after crystal clearance resulted in reduced crystal formation and individual d

SUBMITTER: Ushimoto C 

PROVIDER: S-EPMC12660327 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature