MIAs (Mirror Intracranial Aneurysms): symmetry-related patient risk or consequence of multiplicity?

ABSTRACT:

Purpose

Determine whether mirror intracranial aneurysms (MIAs) confer risk beyond aneurysm multiplicity and describe their distribution and longitudinal change.

Methods

Retrospective two-centre UK cohort of unruptured intracranial aneurysms (UIAs) diagnosed 2006-2020; outcomes to 2022.

Endpoints

first rupture, SAH-specific/all-cause mortality, time to treatment, and lesion-level growth/morphology change. Rates used Poisson models with person-time offsets; lesion-level risks used GEE (modified Poisson). Rupture-free survival used inverse-probability-weighted Kaplan-Meier. Models adjusted for baseline aneurysm count.

Results

1,985 UIAs were identified; 289 (14.6%) were MIAs. MIAs clustered at the MCA bifurcation (57.8%) and ICA terminus (34.6%). First-rupture inc

SUBMITTER: Roj B 

PROVIDER: S-EPMC12660364 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature