Assessing the frequency and accuracy of morphologic changes of focal bone lesions on [⁶⁸Ga]Ga-PSMA-11 PET/CT in prostate cancer.

ABSTRACT:

Background

In [¹⁸F]F-PSMA-1007 PET imaging, focal bone uptake without morphological correlate (MC) on CT, is often classified as benign. In [⁶⁸Ga]Ga-PSMA-11, intense focal uptake without MC in a classical location is considered suspicious. The prevalence of focal bone uptake with or without MC on [⁶⁸Ga]Ga-PSMA-11 PET/CT remains unclear.

Methods

This single-center, retrospective study included patients who underwent a [⁶⁸Ga]Ga-PSMA-11 PET/CT scan for initial staging or biochemical recurrence (BCR) of prostate cancer between 04/16 - 11/21, with written informed consent for use of clinical data and adequate follow-up. For each patient with focal PSMA accumulation in the bones, up to three of these lesions were scored based on PSMA-RAD

SUBMITTER: Sivakumar T 

PROVIDER: S-EPMC12660395 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature