[¹⁸F]AlF-NOTA-FAPI-04 PET/CT improves detection of subcentimeter recurrent lesions in differentiated thyroid cancer.

ABSTRACT:

Purpose

Fibroblast activation protein (FAP)-targeted PET/CT has emerged as a promising tool for visualizing tumor stroma. This study aimed to validate the diagnostic efficacy of [¹⁸F]AlF-NOTA-FAPI-04 PET/CT in detecting subclinical metastases in recurrent differentiated thyroid cancer (DTC), with direct comparison to [¹⁸F]FDG PET/CT.

Methods

Twenty-three DTC participants with biochemical recurrence (suppressed thyroglobulin [Tg] ≥ 1 ng/mL or Tg antibodies [Tg-Ab] > 115 IU/mL) underwent [¹⁸F]AlF-NOTA-FAPI-04 PET/CT, including 16 who underwent paired [¹⁸F]FDG scans. Lesion classification followed histopathology or 15.5-month clinical follow-up (median, 8-32 months).

Results

[¹⁸F]AlF-NOTA-FAPI-04 PET/CT demonstrated

SUBMITTER: Zheng K 

PROVIDER: S-EPMC12660412 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature