Prolonged hypokalemia long after causative factor elimination in pseudo-Bartter/Gitelman syndrome.

ABSTRACT:

Background

Pseudo-Bartter/Gitelman syndrome (PBS/PGS) is caused by medication and lifestyle factors, leading to hypokalemia and potentially impairing kidney function. Treatment primarily involves eliminating the underlying causes, which typically results in rapid improvement. However, PBS/PGS findings may persist long after the removal of causative factors, and its pathogenesis remains unclear.

Methods

This study focused on 49 cases diagnosed with PBS/PGS. All cases presented with hypokalemia, attributed to apparent causes, and comprehensive genetic testing detected no pathogenic variants associated with hereditary kidney diseases. They were categorized into two groups: the current group (n = 39), where causative factors persisted, and the past group (n = 10), where more tha

SUBMITTER: Kondo A 

PROVIDER: S-EPMC12660418 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature