Nanoemulsion encapsulation enhanced the anti-tumor potency of pomegranate polysaccharides by suppressing oxidative stress, inflammation, and tumor metastasis induced by 1,2-dimethylhydrazine in rats.

ABSTRACT: Colorectal cancer (CRC) treatment has progressed, but more effective therapeutic targets are still needed. Pomegranate polysaccharides (PGPs) show promising anti-tumor activity but have limited bioavailability. Their stability and delivery can be improved using nanostructured systems, such as nanoemulsions (NEs). This study investigated the chemopreventive effect of PGPs and their nanoemulsion (PGPs-NE) against 1,2-dimethylhydrazine (DMH)-induced CRC in rats. Male Wistar rats received subcutaneous DMH injections (20 mg/kg) and were orally administered PGPs and PGPs-NE at 200 mg/kg body weight for 12 weeks. CRC progression was assessed by measuring tumor burden, mucosal plaque lesions, aberrant crypt foci (ACF), cecal short-chain fatty acids (SCFAs), oxidative stress markers, liver enzymes,

SUBMITTER: Sadek SA 

PROVIDER: S-EPMC12660450 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature