Comparison of two preprocessing methods for ¹⁸F-Flortaucipir PET quantification in Alzheimer's disease.

ABSTRACT:

Background

Tau-Positron Emission Tomography (PET) has become central in Alzheimer's disease (AD) research and clinical settings. Multiple preprocessing pipelines for tau-PET quantification have been described, with satisfactory performance but direct comparisons remain scarse. Our study evaluates the comparability of two commonly used PET preprocessing methods, respectively in native and standard spaces, in quantifying tau deposition and in their ability to discriminate AD patients.

Methods

209 subjects were included from the Geneva memory clinic including cognitively unimpaired (CU) individuals, mild cognitive impairment (MCI) and dementia patients. Images were processed in native and standard space using inferior cerebellar grey matter as reference region. Standardized upt

SUBMITTER: Harput E 

PROVIDER: S-EPMC12660454 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature