Circulating inflammation-related proteome improves cardiovascular risk prediction. Results from two large European cohort studies.

ABSTRACT:

Background

Inflammation plays a crucial role in cardiovascular disease (CVD), but the value of inflammation-related proteins in predicting major adverse cardiovascular events (MACE) is unclear. This study evaluated whether incorporating inflammation-related proteins into the SCORE2 model improves 10-year MACE risk prediction.

Methods

This study included 47,382 participants from the UK Biobank and 4,135 participants from the German ESTHER study without prior CVD or diabetes. We tested C-reactive protein (CRP) and 73 inflammation-related proteins measured with Olink^® panels. Biomarker selection was performed using least absolute shrinkage and selection operator (LASSO) regression with bootstrapping separately for males and females. Selected proteins were added to th

SUBMITTER: Xie R 

PROVIDER: S-EPMC12660460 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature