PET/CT imaging of esophageal cancer targeting tumor cell specific αvβ6-integrin expression.

ABSTRACT:

Purpose

To assess the potential of αvβ6-integrin as a theranostic target in esophageal cancer.

Methods

Membranous β6-integrin (ITGB6) expression was analyzed in 306 specimens of human esophageal squamous cell carcinoma (ESCC) obtained by immunohistochemistry (IHC) from 100 patient cases (1, 37, 58, and 4 of grade G1, G2, G3, and G4, respectively). Ga-68 labeling of D0103 was done manually for preclinical experiments and fully automated for clinical application. Preclinical characterization of Ga-68-D0103 was performed in SCID mice bearing subcutaneous xenografts of H2009 (αvβ6-positive) or MDA-MB-231 (αvβ6-negative) carcinoma cell lines, by ex vivo biodistribution (10, 30, 90, and 180 min p.i) and PET imaging (30, 90, and 180 min p.i.)., without and with co-injection of gelo

SUBMITTER: Bendova KD 

PROVIDER: S-EPMC12660471 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature