Antiviral and immunomodulatory effects of Chaihu Guizhi decoction in an acute depression-like mouse model infected with influenza A virus.

ABSTRACT:

Background

Chaihu Guizhi Decoction (CGD) is a classical prescription in traditional Chinese medicine (TCM) that has been shown to be effective against infection and depression. However, the mechanisms of action of CGD in treating patients with depression who are also infected with a virus remain unknown. This study investigated the pharmacological mechanisms of CGD in treating depression-like mice infected with influenza A virus (IAV).

Methods

The acute depression-like mouse model infected with IAV was established. The effects of CGD on alleviating depression-like symptoms were observed using the sucrose preference test and monoamine neurotransmitter expression. Additionally, the effectiveness of CGD against infection was assessed by examining the relative expression of the

SUBMITTER: Shi R 

PROVIDER: S-EPMC12660485 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature