The Neurocognitive Impact of CAR T Cell Therapy in Hematological Cancers: A Systematic Review of Cognitive Function, Quality of Life, and Psychological Outcomes.

ABSTRACT:

Background

Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of hematological malignancies, offering durable remissions. However, concerns regarding its neurocognitive and psychological impact have emerged, particularly in patients experiencing immune effector cell-associated neurotoxicity syndrome (ICANS). Despite growing clinical use, the long-term effects on cognitive function, psychological well-being, and quality of life (QoL) remain unclear.

Objective

This systematic review evaluates the neurocognitive, psychological, and QoL outcomes associated with CAR T-cell therapy.

Methods

A systematic search of PubMed, Embase, and Scopus was conducted following PRISMA guidelines. Eligible studies included randomized controlled trials, cohort s

SUBMITTER: Pillai AA 

PROVIDER: S-EPMC12660487 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature