Proteostasis network response to environmental chronic stress: linking survival to protein aggregation in a human neuroblastoma cellular model.

ABSTRACT: Proteins tend to misfold upon stressful events that alter their homeostasis, potentially leading to protein aggregation. A tight regulation of synthesis, folding and degradation, defined as proteostasis network (PN), is required to ensure the functionality of the cell. PN is of utmost importance in post-mitotic cells such as neurons, where protein quality must be preserved for their entire lifetime. Most neurodegenerative disorders are associated with dysregulation of this network. Here, we describe the alteration in key components of the PN during chronic stress and link them with the increase in the amyloid burden and with the aggregation of the protein TDP-43, a major player in Amyotrophic Lateral Sclerosis and other neurodegenerative diseases. Neuroblastoma SH-SY5Y cells were treated w

SUBMITTER: Montalesi E 

PROVIDER: S-EPMC12660585 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature