Exploring putative links between gut microbiota and allergic rhinitis: insights from Mendelian randomization and multi-transcriptome integration.

ABSTRACT: Allergic rhinitis (AR) is a common immune-related disorder recently associated with gut microbiota (GM), though the underlying mechanisms remain unclear. This study employed Mendelian randomization (MR) to investigate causal relationships between GM and AR, combined with transcriptomic analyses, including both bulk and single-cell RNA sequencing (scRNA-seq), to explore molecular mechanisms at tissue and cellular resolutions. Data for AR and GM were sourced from public databases. MR identified causal microbial taxa, whose associated SNPs were mapped to genes. These were intersected with differentially expressed genes (DEGs) from transcriptomic data to identify candidate genes. Key genes were validated through expression analysis, immune infiltration, functional enrichment, regulatory networ

SUBMITTER: Zhu J 

PROVIDER: S-EPMC12660600 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature