T-cell immunoglobulin and mucin domain-containing protein 3-mediated immunomodulation in myeloid cells and keratinocytes in the development of severe acne.

ABSTRACT: Acne vulgaris is a common chronic inflammatory skin disorder with significant clinical and societal impacts. Severe acne (SA), in particular, causes scarring, disfigurement, and psychosocial distress. The underlying pathogenesis of SA remains poorly understood, hindering the development of effective treatments. In our study, single-cell RNA sequencing (scRNA-seq) of samples from SA, acne, and normal skin was performed, 12 clusters were identified from the total cell population, and macrophages were considered as important cell clusters since all gene modules showed high gene activity for macrophages in the scRNA weighted correlation network analysis (WGCNA). By integrating macrophage-specific differentially expressed genes (DEGs) with Mendelian randomization (MR) analysis, it was found tha

SUBMITTER: Chen S 

PROVIDER: S-EPMC12660616 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature