Fibrinogen alpha and beta chains as non-invasive predictors of hepatocellular carcinoma progression.

ABSTRACT: Hepatocellular carcinoma (HCC) poses a significant global health burden due to its high incidence and mortality rates. Early diagnosis is crucial for improving patient outcomes; however, current diagnostic methods, such as the measurement of α-fetoprotein (AFP) levels, have notable limitations. Our study aimed to explore non-invasive markers with superior diagnostic efficacy for HCC. Our findings revealed a significant downregulation of FGA, FGB, and FGG in HCC, with lower expression levels strongly associated with reduced overall survival and disease-free survival rates. Notably, the diagnostic accuracies of FGA and FGB in detecting HCC, particularly in its early stages, surpassed that of AFP. ELISA results further confirmed the reduced serum levels of these proteins in HCC patients. In a

SUBMITTER: Kim HS 

PROVIDER: S-EPMC12660675 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature