Dynamic changes in hemispheric lateralization in major depressive disorder correlate with neurotransmitter and genetic profiles: a DIRECT consortium study.

ABSTRACT: Hemispheric lateralization, recognized as a pivotal feature in both the structural and functional organization of the human brain, may undergo alterations in specific psychiatric disorders. However, the time-varying patterns of hemispheric lateralization in individuals with major depressive disorder (MDD) and the relationship between these patterns and gene expression profiles remain largely unexplored thus far. Using a large multi-site resting-state functional magnetic resonance imaging (rs-fMRI) data encompassing 2611 participants (1660 MDD patients and 1341 healthy controls), we examined MDD-related abnormalities in dynamic laterality and its association with clinical symptoms, meta-analytic cognitive functions, and neurotransmitter receptor profiles, respectively. And the biological ba

SUBMITTER: Ping LL 

PROVIDER: S-EPMC12660689 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature