M6A regulators-based gene expression pattern is associated with immune microenvironment characteristics in hepatocellular carcinoma.

ABSTRACT: To evaluate the relationship between N6-methyladenosine (m6A) modification-related genes and the immune microenvironment characteristics of hepatocellular carcinoma (HCC), and to evaluate the potential of targeting m6A regulators to sensitize HCC cells to immunotherapy. RNA sequencing data and clinicopathologic data of HCC patients were obtained from TCGA and ICGC database. Based on the expression levels of 23 m6A modification regulators, the HCC samples were divided into three m6A clusters by ConsensusClusterPlus algorithm. Survival analysis and clinical features was explored in different clusters. Next, univariate Cox analysis and LASSO regression analysis were applied to screened out 4 immune-related prognostic genes from the differentially expressed genes (DEGs) in the three clusters,

SUBMITTER: Wang W 

PROVIDER: S-EPMC12660722 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature