Behavioral and molecular insights into anxiety in ube3a and fmr1 zebrafish models of autism spectrum disorders.

ABSTRACT: Angelman syndrome and Fragile X syndrome are neurodevelopmental disorders (NDDs) caused by mutations in the UBE3A and FMR1 genes, respectively. However, they share common features such as cognitive and motor deficits, anxiety, and impaired social behavior. In this study, we utilized zebrafish as an animal model to investigate the anxiety-like effects of mutations in these genes across larval and adult stages, employing two widely used behavioral assays: the light-dark test (LDT) and the novel tank diving test (NTT). We conducted detailed analyses of anxiety-like behaviors and exploration patterns in ube3a and fmr1 mutant fish, comparing both genotypes to their respective wild-type (WT) counterparts. Importantly, we analyzed RNA sequencing data from both larvae and adults to better understa

SUBMITTER: Dougnon G 

PROVIDER: S-EPMC12660731 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature