Space radiation induces distinct senescent phenotypes: Implications for space travel.

ABSTRACT: As Earth's magnetic field weakens, space radiation begins to pose a significant threat to the health of not only space travelers, but the world's population. Space radiation, comprising high-energy and high-charge ions, creates distinct clusters of DNA damage and dense macromolecular damage that result in the accumulation of senescent cells (SnCs) known to play a critical role in promoting multimorbidity. Here, we demonstrate that human fibroblasts exposed to different forms of space radiation acquire senescence-associated phenotypes including morphological alterations and the accumulation of SA-ß-gal⁺ cells to a greater extent than what is observed following γ-irradiation. Bulk and single cell RNA (scRNAseq) sequencing analysis revealed that space irradiated human fibroblasts u

SUBMITTER: Pitcher LE 

PROVIDER: S-EPMC12660773 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature