Altered sphingolipid profile in primary biliary cholangitis: associations with fibrosis and inflammation.

ABSTRACT: Sphingolipids, key bioactive lipids implicated in inflammation, immune regulation, and fibrosis, are increasingly recognized as contributors to liver pathophysiology. However, their role in primary biliary cholangitis (PBC) remains poorly characterized. In this study, we examined plasma sphingolipid profiles in 45 patients with early-stage PBC receiving ursodeoxycholic acid therapy, comparing them to 30 healthy controls using ultra-high-performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS). PBC patients exhibited significantly reduced total sphingolipid levels, notably in phosphorylated species such as sphingosine-1-phosphate (S1P) and sphinganine-1-phosphate (SPA1P). In contrast, C18:1-ceramide was elevated and showed a trend toward association with increas

SUBMITTER: Rogalska M 

PROVIDER: S-EPMC12660775 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature