FOXO1-driven metabolic reprogramming of hematomal CD8⁺ T cells drives the expansion of perihematomal edema following intracerebral hemorrhage.

ABSTRACT: Intracerebral hemorrhage (ICH) causes hematoma formation, leading to PHE, which is associated with leukocyte mobilization and increased inflammation at the site of brain injury. However, the fate of accumulated leukocytes within the hematoma and their impact on PHE expansion remain unknown. We performed single-cell immune profiling of hematoma cells from patients with acute ICH and reported a distinct phenotypic transformation of CD8⁺ T cells within the hematoma during the first 24 h after onset. In addition to enhanced IFN-γ production and migration capacity, these CD8⁺ T cells displayed remarkable glycolytic signatures. The metabolic fitness and functional reprogramming of hematomal CD8⁺ T cells are associated with the transcription factor FOXO1. Single-c

SUBMITTER: Lin J 

PROVIDER: S-EPMC12660799 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature