Subthalamic stimulation shifts brain network dynamics from extensive functional support to motor dominance in Parkinson's disease.

ABSTRACT: Therapeutic deep brain stimulation (DBS) rebalances local motor circuitry activity in Parkinson's disease (PD). However, the mechanistic understanding of how DBS impacts global macroscale dynamic functional network states remains limited, particularly regarding its effects on motor and non-motor networks. To address this, we employed an algorithm for dynamic functional connectivity co-activation patterns (DFCCAP) based on fMRI data to identify intrinsic macroscale neural states in the brain of healthy elderly individuals. Furthermore, by conducting a statistical analysis of the spatiotemporal properties of these patterns under different acquisition parameters and regional parcellation resolutions, we demonstrated the reproducibility of the results. Building on this, we examined 27 PD patie

SUBMITTER: Chu C 

PROVIDER: S-EPMC12660807 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature